Endocrine Abstracts

Introduction: Premature pubarche (PP) is most often related to idiopathic premature adrenarche (IPA). However, it is a diagnosis of exclusion and differential diagnosis must include milder and nonclassic variants of congenital adrenal hyperplasia (CAH).Purpose: To identify clinical predictors of CAH and IPA in children with PP.Materials and methods: A retrospective study was conducted including children seen for PP between 2001 and...

Introduction: Radiation therapy is an effective treatment for relapsing or recurrent pituitary functioning adenomas, providing tumor volume control and hormone secretion normalization. However, there are several secondary effects to consider.Aims: To assess the efficacy of radiotherapy in the management of patients with acromegaly and Cushing’s disease (CD) treated in our Department, and the prevalence of radiation secondary effects.<p class="ab...

Introduction: Our group has a bank of human primary thyroid cultures (BANTTIC) obtained from patients. All are individual cultures specifically genotyped and phenotyped. We believe of great interest the search for biomarkers in these cultures using differential proteomic analysis.We have applied differential proteomics using 2D-PAGE coupled to MALDI-TOF-TOF-MS. We have compared benign pathologies (normal thyroid and Pendred’s syndrome) and different...

Introduction: Our aim was to determine the comparable value of thyroglobulin in the washout of lymph node fine-needle aspirate (FNATg) and fine-needle aspiration biopsy (FNAB).Materials and methods: We included 29 patients (37 FNAB) with history of differentiated thyroid cancer who underwent total thyroidectomy and were found to have suspicious cervical lymph nodes during follow-up. The referred population was evaluated on what concerns to gender, age, s...

Background: Pituitary apoplexy occurs when a tumor undergoes acute hemorrhage, infarct, or both. This often leads to acute severe symptoms (clinical) but can also occur without them and diagnosed on CT/MRI, surgery, pathology (subclinical). To investigate clinical and subclinical apoplexy in nonfunctioning tumors (n=221) from our database.Design: Retrospective review of clinical presentation, tumor characteristics and outcome of 24 patients, 11 fe...

Introduction: Fine needle biopsy (FNB) is a very important diagnostic tool in the assessment of thyroid nodules and plays a prominent role in therapeutic approach. It has a sensitivity around 83 to 85% and a specificity around 80 to 92%.Aims: To correlate cytological (FNB) and final histopathological data in patients with nodular thyroid pathology.Methods: A retrospective study of patients who underwent surgical procedure from Janu...

Introduction: Gastric endocrine tumors (GET) are rare. Type 1 tumors are non-functioning, almost exclusively benign lesions, usually presenting as multiple polyps, usually <1 cm in diameter, which arise from gastric enterochromaffin-like cells in response to chronically elevated gastrin, secondary to (auto-immune) atrophic fundic gastritis. These tumors were traditionally treated with total gastrectomy, like adenocarcinomas. Currently, surveillance or endoscopic treatment ...

Introduction: Amiodarone-induced thyrotoxicosis(AIT) is a condition fraught with difficulties from the diagnostic and therapeutic standpoints. It can be developed precociously or years after the beginning amiodarone uptake and after its suspension. AIT is subdivided in three different forms. Type 1 is developed in subjects with underlying thyroid disease, being caused by an exacerbation by iodine load of thyroid autonomous function. Type 2 is a form of destructive thyroiditis ...

Introduction: Obesity has been associated with increased androgenicity in women, however there are conflicting data on this subject. Objectives: To determine whether any androgen is independently related to body mass index (BMI), waist-to-hip ratio (WHR) or age. To access if there is an association between elevated plasma androgen levels and the presence of either morbid obesity or metabolic syndrome (MS).Design and Methods: A total of 148 obese women we...

A positive association between thyrotropin (TSH) secretion and body-mass index (BMI) was previously reported. There are many studies concerning thyroid function in obesity, and some of them describe higher TSH levels in obese subjects.Evaluation of the hypothyroidism prevalence in a sample of obese women in their first obesity appointment at Hospital São João.Anthropometric variables and serum levels of TSH, free triiodot...